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Journal: Aging (Albany NY)
Article Title: Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers
doi: 10.18632/aging.202388
Figure Lengend Snippet: The bioinformatics discovery of breast cancer non-coding RNA biomarkers. ( A ) The abnormal amplification of hsa-miR-423-5p is shown from the cbioportal analysis. ( B ) hsa-miR-423-5p is significantly expressed in the TCGA RNA sequencing datasets. ( C ) A total of 2859 high confidential hsa-miR-423-5p target lncRNAs are found. ( D ) hsa-miR-423-5p target mRNAs enriched in a number of in cancer-relevant pathways indicate that hsa-miR-423-5p plays a pivotal role in the communication of cancer signaling. ( E , F ) Two independent microarray data show that hsa-miR-423-5p is not abnormally expressed in breast cancer metastatic tissue compared to the primary tumor, suggesting that hsa-miR-423-5p does not maintain its regulatory role in the advanced stage of breast cancer. ( G ) Online survival analysis shows that abnormal hsa-miR-423-5p expression is not associated with breast cancer survival.
Article Snippet: RNA sequencing data of both serum and exosomes were processed and assessed by a
Techniques: Amplification, RNA Sequencing Assay, Microarray, Expressing